Arrestin Scaffolds NHERF1 to the P2Y12 Receptor to Regulate Receptor Internalization
نویسندگان
چکیده
منابع مشابه
Arrestin scaffolds NHERF1 to the P2Y12 receptor to regulate receptor internalization.
We have recently shown in a patient with mild bleeding that the PDZ-binding motif of the platelet G protein-coupled P2Y(12) receptor (P2Y(12)R) is required for effective receptor traffic in human platelets. In this study we show for the first time that the PDZ motif-binding protein NHERF1 exerts a major role in potentiating G protein-coupled receptor (GPCR) internalization. NHERF1 interacts wit...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2012
ISSN: 0021-9258
DOI: 10.1074/jbc.m112.347104